Abstract: Ginsenosides are one of the main active components of the plants, which belong to the genus Panax of Araliaceae family. Studies have shown that the pharmacological effects of rare saponins, produced by metabolism in vivo, on anti-tumor, anti-inflammatory and anti-aging are stronger than those of the prototype saponins. Therefore, preparation of rare saponins has become a popular topic in the field of ginseng research. Enzymatic transformation of ginsenosides is one of the primary ways for the preparation of rare saponins, in which many breakthroughs have been made recently. In this paper, the results of these studies were reviewed from the perspectives of different glycosidase types as well as their applications in rare saponins biotransformation so that it could lay a solid foundation for the large-scale development and utilization of rare saponins.

Key words: rare ginsenosides, enzymatic transformation, glycosidase

摘要： 人参皂苷是五加科人参属植物的主要活性成分之一。研究表明，人参皂苷经过体内代谢后生成的稀有皂苷在抗肿瘤、抗炎、抗衰老等方面的药理作用要强于原型皂苷，因此，稀有皂苷的制备成为目前人参研究领域的热点内容。人参皂苷的酶转化是稀有人参皂苷制备的主要途径之一，近些年取得了突破性的进展，以不同种类的糖苷酶为切入点，将相关研究内容进行了综述，分别讨论了不同类型的糖苷酶在稀有皂苷生物转化过程中的应用，以期为稀有皂苷的大规模开发利用奠定基础。

关键词: 稀有人参皂苷, 酶转化, 糖苷酶