Curr. Biotech. ›› 2016, Vol. 6 ›› Issue (4): 271-276.DOI: 10.3969/j.issn.2095-2341.2016.04.09

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Study of the Secondary Metabolism from Salt-tolerant Coralloccus macrosporus

HUANG Yan, ZHU Hong-hui   

  1. 1.State Key Laboratory of Applied Microbiology Southern China; Guangdong Provincial Key Laboratory of
    Microbial Culture Collection and Application; Guangdong Open Laboratory of Applied Microbiology, Guangdong
    Institute of Microbiology, Guangzhou 510070, China;
    2.Foshan Haitian (Gaoming) Flavouring & Food Co., LTD., Guangdong Foshan 528511, China
  • Received:2016-03-16 Online:2016-07-25 Published:2016-04-04

一株陆生耐盐珊瑚球菌次生代谢产物的研究

黄艳1,2,朱红惠1*   

  1. 1.广东省微生物研究所, 华南应用微生物国家重点实验室; 广东省微生物菌种保藏与应用重点实验室; 广东省微生物应用新技
    术公共实验室, 广州 510070;
    2.佛山市海天（高明）调味食品股份有限公司, 广东 佛山 528511
  • 通讯作者: 朱红惠，研究员，博士，研究方向为微生物资源的挖掘、保藏及应用。E-mail:zhuhh@gdim.cn
  • 作者简介:黄艳，工程师，研发方向为微生物发酵和过程控制。E-mail:huang.yan14@qq.com。
  • 基金资助:

    国家自然科学基金项目（31170009；31470141）；广东省科技攻关项目（2012B050700009）资助。

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Abstract: In order to isolate and identify the activated lead compound, we studied the chemical constituents from salt- tolerant Coralloccus 5X1 that extracted by ethyl acetate. The compounds were isolated by silica gel column, Sepha-dex LH-20 column chromatography and HPLC techniques. And these compounds were identified by the physico-chemical properties and spectral analysis. The results showed that there were  three compounds isolated from the ethyl acetate extracts of salt-tolerant Coralloccus 5X1. They were identified as cyclo(Tyr- Pro), cyclo(Phe-Pro) and N-(2-phenylethyl)-acetamide. All of the compounds were isolated from Coralloccus for the first time.

Key words: salt-tolerant Coralloccus, secondary metabolism, cyclo-dipeptide

摘要： 研究了陆生耐盐珊瑚球菌(Coralloccus)5X1发酵液经乙酸乙酯萃取后的化学成分,以期得到有活性的先导化合物。采用硅胶柱 色谱、凝胶柱色谱、高效液相色谱等方法进行分离纯化,通过理化性质和波谱数据分析鉴定化合物的结构。结果显示，从陆生 耐盐珊瑚球菌5X1的乙酸乙酯萃取物中分离得到3个化合物,分别鉴定为环(酪氨酸-脯氨酸)、环(苯丙氨酸-脯氨酸)和乙酰基苯 乙胺。这3种化合物均为首次从陆生耐盐珊瑚球菌5X1中分离得到。

关键词: 耐盐珊瑚球菌, 次生代谢产物, 环二肽

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