关键词: 甲状腺肿瘤, 肿瘤模型, 3D生物打印

Abstract:

The incidence of thyroid tumors has been increasing annually. Traditional pathological diagnosis relies on surgically resected samples， which are invasive and often scarce， limiting the progress of precision medicine. Recent advances in biotechnology and materials science have made 3D bioprinting a vital tool in tumor research. Conventional methods for obtaining thyroid tumor models， such as two-dimensional cell cultures or organoids derived from biopsy or surgical samples， struggle to accurately mimic the complexity of human tumors. 3D bioprinting offers a novel approach for constructing thyroid tumor models by closely simulating the tumor microenvironment， including extracellular matrix composition and mechanical properties that resemble in vivo conditions. Through parameter optimization and the use of advanced bioinks， post-printing cell viability exceeds 90%， providing a powerful platform for investigating tumor mechanisms and developing new drugs. These bioprinted models enable rapid drug screening， reducing experimental timelines by approximately 50% while improving the accuracy of drug response predictions. This supports more informed clinical decision-making for precision therapy. This review summarized recent progress and potential applications of 3D bioprinting in thyroid tumor models constructing. It highlighted the technology's role as an efficient tool for pathological studies， drug development， and personalized treatment， potentially lowering medical costs and improving patient outcomes. By offering valuable insights for thyroid researchers， 3D bioprinting promises to advance both basic research and clinical management of thyroid tumors.

Key words: thyroid cancer, tumor model, 3D bioprinting